Non-Uremic Calciphylaxis: An Unexpected Complication With Recombinant Human Parathyroid Hormone
نویسندگان
چکیده
منابع مشابه
Parathyroid hormone, a uremic toxin.
Despite the innovations in the treatment of secondary hyperparathyroidism, there are uremic patients with marked elevation in PTH levels. Uremic toxicity is in part attributable to the excess of circulating PTH. It has been known for many years that PTH may induce changes in cell calcium, a key intracellular signal required for normal cell function. The effect of PTH in dialysis patients is not...
متن کاملRecombinant human parathyroid hormone 1-84 (Natpara)
Description/Mechanism of Action Recombinant human parathyroid hormone (rhPTH 1-84) is identical to endogenous parathyroid hormone (PTH) and binds PTH-1 receptors in the bone, kidney, and has an indirect effect on calcium reabsorption in the intestine. It increases serum calcium by increasing renal tubular calcium reabsorption, intestinal calcium absorption, and bone turnover. Indication under R...
متن کاملNon-uremic calciphylaxis and Chagas disease.
a Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ciudad Universitaria, Paraje ‘‘El Pozo’’, Santa Fe, CP: 3000, Argentina b Servicio de Clínica Médica, Hospital J.B ‘‘Iturraspe’’, Bv. Pellegrini 3551, Santa Fe, CP: 3000, Argentina c Instituto de Inmunología, Facultad de Medicina, Universidad Nacional de Rosario, Santa Fe 31...
متن کاملPurification and characterization of recombinant human parathyroid hormone-related protein.
Full-length human parathyroid hormone-related protein (PTHrP-(1-141] as well as a carboxyl-terminal shortened form (PTHrP-(1-108] have been expressed from recombinant DNA-derived clones. These proteins were expressed in Escherichia coli as fusion proteins so that cyanogen bromide cleavage yields the desired product. Both proteins were purified and then characterized by sodium dodecyl sulfate ge...
متن کاملUse of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy.
Hypocalcemia secondary to hypoparathyroidism is a rare cause of congestive heart failure. However, its early recognition and treatment lead to significant improvement in cardiac function. We report a middle-aged woman presenting with symptoms of heart failure with a serum calcium level of 3.7 mg/dl and a serum inorganic phosphate level of 17.6 mg/dl 22 years after subtotal thyroidectomy. Beside...
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ژورنال
عنوان ژورنال: Cureus
سال: 2021
ISSN: 2168-8184
DOI: 10.7759/cureus.15014